Glomerulopathies
Diseases of the genitourinary system

Glomerulopathies (GP) is a group of diseases that injure the part of the kidney that filters blood (called glomeruli). Other terms you may hear used are nephritis and nephrotic syndrome. When the kidney is injured, it cannot get rid of wastes and extra fluid in the body. If the illness continues, the kidneys may stop working completely, resulting in kidney failure.

There are two types of GP —acute and chronic. The acute form develops suddenly. You may get it after an infection in your throat or on your skin. Sometimes, you may get better on your own. Other times, your kidneys may stop working unless the right treatment is started quickly. The early symptoms of the acute disease are:

• puffiness of your face in the morning
• blood in your urine (or brown urine)
• urinating less than usual.

You may be short of breath and cough because of extra fluid in your lungs. You may also have high blood pressure. If you have one or all of these symptoms, be sure to see your doctor right away.

The chronic form may develop silently (without symptoms) over several years. It often leads to complete kidney failure. Early signs and symptoms of the chronic form may include:

• Blood or protein in the urine (hematuria, proteinuria)
• High blood pressure
• Swelling of your ankles or face (edema)
• Frequent nighttime urination
• Very bubbly or foamy urine

Symptoms of kidney failure include:

• Lack of appetite
• Nausea and vomiting
• Tiredness
• Difficulty sleeping
• Dry and itchy skin
• Nighttime muscle cramps

Sometimes, the disease runs in the family. This kind often shows up in young men who may also have hearing loss and vision loss. Some forms are caused by changes in the immune system. However, in many cases, the cause is not known. Sometimes, you will have one acute attack of the disease and develop the chronic form years later.